The Invasion Image
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The Invasion Image
Citation: For gallantry and intrepidity at the risk of his life above and beyond the call of duty on 6 June 1944, in France. After 2 verbal requests to accompany the leading assault elements in the Normandy invasion had been denied, Brig. Gen. Roosevelt's written request for this mission was approved and he landed with the first wave of the forces assaulting the enemy-held beaches. He repeatedly led groups from the beach, over the seawall and established them inland. His valor, courage, and presence in the very front of the attack and his complete unconcern at being under heavy fire inspired the troops to heights of enthusiasm and self-sacrifice. Although the enemy had the beach under constant direct fire, Brig. Gen. Roosevelt moved from one locality to another, rallying men around him, directed and personally led them against the enemy. Under his seasoned, precise, calm, and unfaltering leadership, assault troops reduced beach strong points and rapidly moved inland with minimum casualties. He thus contributed substantially to the successful establishment of the beachhead in France.
Zelensky declared martial law early Feb. 24 and urged Ukrainians to stay at home and to remain calm. The Ukrainian leader said that he had asked for a call with Putin late Wednesday before the invasion, but that the Kremlin did not respond. Thousands of Ukrainian citizens have attempted to flee major cities, including Kyiv, while others have taken shelter in subway stations or makeshift bunkers.
Since Russia's invasion of Ukraine began, an estimated 1 million have fled to neighboring E.U. states, according to the United Nations. Tens of thousands have also enlisted in the military in the week since Russia's invasion began. Ukraine's defense ministry reported Thursday, March 3, that they'd get help from roughly 16,000 military volunteers, too.
U.S. officials had said for weeks that a Russian invasion of Ukraine was imminent, a warning that Russia, in turn, dismissed as scaremongering. U.S. President Joe Biden warned of a "catastrophic loss of life and human suffering."
The U.S. has joined international partners in levying heavy new sanctions against Russia's military and economy in the days since the invasion began. President Biden has said that Russian President Vladimir Putin and his country would bear the costs of the attack.
A couple embraces before the woman boards a train leaving for western Ukraine, at the railway station in Kramatorsk, eastern Ukraine, on Sunday. The U.N. refugee agency says nearly 120,000 people have so far fled Ukraine into neighboring countries in the wake of the Russian invasion. Andriy Andriyenko/AP hide caption
Phenotypic heterogeneity is widely observed in cancer cell populations. Here, to probe this heterogeneity, we developed an image-guided genomics technique termed spatiotemporal genomic and cellular analysis (SaGA) that allows for precise selection and amplification of living and rare cells. SaGA was used on collectively invading 3D cancer cell packs to create purified leader and follower cell lines. The leader cell cultures are phenotypically stable and highly invasive in contrast to follower cultures, which show phenotypic plasticity over time and minimally invade in a sheet-like pattern. Genomic and molecular interrogation reveals an atypical VEGF-based vasculogenesis signalling that facilitates recruitment of follower cells but not for leader cell motility itself, which instead utilizes focal adhesion kinase-fibronectin signalling. While leader cells provide an escape mechanism for followers, follower cells in turn provide leaders with increased growth and survival. These data support a symbiotic model of collective invasion where phenotypically distinct cell types cooperate to promote their escape.
To probe the biology of a rare and phenotypically heterogeneous cell populations, single cells or subclones need to be isolated based upon user-defined criteria, instead of a random iso